The title refers to the address of the offices and recording studios of Chess Records and Checker Records in Chicago where the five songs for the EP were recorded in June 1964.
AllMusic reviewer Richie Unterberger described the song as a great groovin' original blues-rock jam. The song was originally released at just over two minutes in length, fading early for lack of time available on a conventional EP in 1964. A full length (3:38 minute) version appears on the 1964 West German Decca LP Around And Around, and the 2002 CD re-release of 12 X 5. There is also a rarer second take which has a rougher, more blues-based sound than the better known Five by Five rock-groove version. This version, with its short but distinctive tremolo guitar riff, was under consideration as the title track of an eventually unreleased 1964 blues album.